Angiogenic mediators plasma response to aerobic exercise with crataegus elbursensis extract in male's rat

Background: Angiogenic factors are set of growth factors that directly and indirectly enhances vessels in the tissue

On the other hand, seem to medicinal extract some herbs can interact with growth factor pathways

Objective: The aim of this study was to determine the effect of six weeks of progressive aerobic training and aqueous extract of Crataegus monogyna on VEGF variations and plasma angiopoetin-1/2 in male Wistar rats

Methods: 32 male Wistar rats, 4-6 months old, were randomly divided into four groups: control Crataegus monogyna, training Crataegus monogyna, control saline and training saline

A milli liter aqueous extract of Crataegus monogyna 100 g per body weight orally immediately after training, five days in a week for six weeks from the end of the second week was given to mice

Data were analyzed using one-way ANOVA at the significant level P<0.05

Results: the results showed that progressive endurance training reduced VEGF of plasma in the training group, Crataegus monogyna group and training-Crataegus monogyna group comparing the control group. Plasma ANG-1 concentration reduced in the training, Crataegus monogyna and training-Crataegus monogyna groups while plasma ANG-2 concentration significantly increased in the Crataegus monogyna group [P=0.022] comparing with the control group

The ratio of plasma ANG-2 to ANG-1 significantly increased in the Crataegus monogyna group [P=0.028] comparing with the control group

Conclusion: The findings suggest that combination of aerobic training and Crataegus monogyna extract has no synergistic effect on anti-angiogenesis indicators

Comparison between the effects of eight weeks of aerobic and resistance training on paraoxonase-1, arylesterase activity andlipid profile in obese girls

Background and Aim: The aim of this study was to make a comparison between the effects of eight weeks aerobic and resistance training on paraoxonase-1, arylesterase activity and lip id profile in obese girls

Material and method: 30 obese women with mean values for age 30+/-5years, height 1.60+/-2m and weight 85.23+/-6.7kg, and body mass index of 31-33kg/m[2] were divided randomly into three aerobic exercise [n=10], resistance training [n=10] and control [n=10] groups. Experimental groups performed aerobic exercise on treadmill between 60 to 75% of heart rate reserve and resistance training between 55 to 75% 1RM for 8 weeks

Blood samples were taken from the subjects 48 hours before and 48 hours after training and also after 12 hours of fasting. Data were analyzed by use of ANOVA and Tukey post hoc test. P<0.05was considered significant

Results: The results showed that aerobic exercise had a significant effect on serum concentrations of paraoxonase-1 [PM3.001] and arylesterase [P=0.006] in obese girls

However, there was no significant difference between the effects of eight weeks of aerobic and resistance training on the plasma levels of cholesterol, triglycerides and LDL in obese girls [P<0.05]

Also, the results showed that plasma HDL levels significantly increased after eight weeks of aerobic training in obese girls [P=0.007]

The effects of eight weeks of aerobic and resistance training on plasma VLDL level, were significantly different from those of the control group [P=0.001]

Conclusion: According to the results of this study, it seems that aerobic exercise can increase paraoxonase-1 and arylesterase plasma levels and also modify lip id profile which can result in reduced risk of cardiovascular diseases in obese people

Dermatofibrosarcoma protuberans of Darier and Ferrand

Individualized as a real anatomo-clinical entity in 1924 by Darier and Ferrand, the dermatofibrosarcoma protuberans is a rare cutaneous tumor of intermediate wickedness, which is characterized by its slow evolution, its local aggressiveness, a high power of recurrence and the rarity of metastases. Our casuistry lasts from february 2001 to october 2010 when 22 cases were supported. We distinguish 15 men and 7 women, whose average age was 42 years, ranging from 11 years to 64 years. Surgical excision of the tumor was large, with safety margins of 5 cm in 21 patients and 3 cm for a neck tumor. Of the 13 patients treated in first intention, none has recurred with a mean of 7 years. Other patients complain only one recurrence. None of our patients presented metastasis. The dermatofibrosarcoma mainly affects young adults with a slight male predominance. Its clinical diagnosis is difficult in the beginning stage, but he is more evident in the state phase. Histology, immunohistochemistry and the immunolabelling of the CD34 antigen, confirm the diagnosis. Different techniques can cover losses of substance caused by this mutilating surgery. Tumors are all of size greater than 5cm. Treatment is always surgical and must satisfy two principles: a wide margin of excision in the area and the sacrifice of a healthy anatomical barrier in depth

Principles of surgical treatment of malignant tumors skin

Malignant skin tumors are the most common human cancers in general, their incidence is steadily increasing due to longer life and behavioral habits, especially repeated sun exposure. We describe a series of 150 cases of skin tumors between October 1995 and January 2007. Most tumors are at the head. The age of the patients ranged from 10-75 years. Oncologic resection must meet specific margins for each type of tumor. The reconstruction is made after histological confirmation. Re We regret no serious complications postoperatively . One case of recurrence in a spinocellular carcinoma of the cheek, 1 year after treatment, is to report. If the vast majority of skin cancer have a good prognosis, their recurrent and multiple character and the fact that they affect more elderly population are so brittle they still represent a serious public health problem . Basocellular carcinomas are the most frequent tumors, they are slow growing, mostly local, which virtually never metastasize . Spinocellular carcinomas have a much more aggressive local development and can metastasize . Melanomas are the most dangerous malignant cutaneous tumors. Dermatofibrosarcoma protuberans never metastasis, its evolution is slow, his aggressiveness is local but has a tendency to relapse .The treatment of malignant skin tumors is surgical in the majority of cases. Oncologic resection must meet specific margins for each type of tumor. The cover is made after histological confirmation, it uses a skin graft or local flap coverage

[ Mc Kissock breast reduction]

Breast hypertrophy is an excessive volume of breasts compared to the morphology of the woman. Among the many existing surgical techniques to treat it the Mc Kissock technique has widely recognized benefits. This is a 36 years old patient who has breasts hypertrophy, pain, postural changes with an impact on the static spine. The technique of breast reduction used is a vertical bipedicle flap. The postoperative course is simple and the patient is very satisfied with of the results with a decline of 6 months. This technique can be used for all types of hypertrophy. It is characterized by the ease and reproducibility of preoperative design, the simplicity of gesture and high vascular safety. The disadvantages are large inframammary scars and the difficulty of adequately plicaturing the double pedicle in large hypertrophy and ptosis. The Mc Kissock Breast reduction gives good functional and aesthetic results, it is a technique of choice in the treatment of breast hypertrophy

[Interest hamstring flap in the coverage of ischial pressure sores]

The ischial pressure ulcer, a condition common in the paraplegic patient in a wheelchair, are deemed to be poor prognosis made frequent recurrences after surgery. We hope to show in this work the interest and superiority shreds hamstrings in their care compared with other surgical techniques. A series of 20 ischial pressure ulcer operated in our department over a period of eight years with a mean of four years is analyzed and compared with literature data The optimal rate of recurrence found in the literature is 20%. all of these results highlights the importance of choosing the cover and flap. Quality followed postoperatively. Different surgical techniques are discussed including: the gluteus maximums, slender, tensor fascia lata fasciocutaneous thigh flap, rectus femoris, vastus lateralis, rectus abdominis, the most complex cases and the most extreme indications are described as. The treatment of ischial pressure ulcer is heavy and requires a multidisciplinary team to improve prognosis

[Care of a gigantomasty]

This is a rare, benign and of unknown etiology illness that is characterized by abnormal and excessive development of the breasts. It occurs most often during puberty or during pregnancy. Its physical and psychological impacts requires a quick and efficient care. This is a 15 years old patient who received a breast reduction called Thorek. This technique is particularly suitable for the treatment of advanced gigantomasty. The intervention was successful in removing more than 4 kgs in each of two breasts. The postoperative course is simple and the patient is very satisfied with the result with a decline of 18 months. The disease is defined by a breast volume superior to 1500 cm3. This results in a psychological distress and physical discomfort. Its treatment is surgical and involves the reduction mammoplasty that can be either conservative or radical. The most common techniques used are the Mc Kissock and Thorek. Our preference goes to the Thorek because it respects the viability of the areola and minimizes the risk of local complications: oedema, ulceration, necrosis, infection. The technique of Thorek used to treat the gigantomasty of our patient gave satisfactory results in terms of function and aesthetics. However, she remains under regular survey because of recurrences that are common and may require reoperation

[Reconstruction of the lower lip by the Karapandzic flap]

The main etiology of the defects of the face is the excision of skin tumors. Lip reconstruction or cheiloplasty can use several techniques. Karapandzic flap provides good coverage of these losses of substances with good aesthetic and functional results. A 67 years old patient presents a spinocellular carcinoma of the lower lip measuring 4.5 cm × 4 cm. Resection repects a margin of 1cm. A bilateral rotation flap wich incisions are parallel to the free edges of the lips and equal to the height of the defect was performed. A back cut on the mucosal side allows better advancement of the flaps. They are sutured to each other. The postoperative course is simple. The aesthetic and functional results are very satisfactory with a decline of 6 months. This is an excellent technique because it bends to the principles that are functional, morphological and aesthetic. It respects vessels: coronary facial artery, sensory and motor branches of the myocutaneous flap to obtain a buccal sphincter effective immediately. The mouth opening is satisfactory due to the elasticity of the tissue flap. Secondary commissuroplasty is not systematic. Most often, the incision seat in the nasolabial fold and goes higher or lower depending on the size of the defect. The upper limit of the incision is a few millimeters below the nostril. The Karapandzic flap used to the lower lip reconstruction after tumor resection gave good functional, morphological and aesthetic results

Animal fascioliasis in coastal regions of the Caspian Sea, Iran [2006-2007]

To determine the prevalence of animal fascioliasis in coastal regions of the Caspian Sea, during 2006-2007, a total of 2368 faecal samples were collected from sheep [n=1250], cattle [n=975] and horse [n=143]. The samples were obtained directly from the rectum of animals. Floatation method was performed for determination of egg per gram of faeces [EPG]. Our findings revealed the presence of Fasciola spp. eggs in 9.53, 7.8 and 2.5% of sheep and 32.5, 12.1 and 3.1% of cattle in Gilan, Mazandaran and Golestan, respectively. Among the horse faecal samples collected from Golestan and Gilan provinces, no eggs were found in Golestan, while 50% of those of Gilan were infected with Fasciola spp. Cattle was one of the most infected animals in the studied areas. A positive correlation was found between climatic conditions and animal fascioliasis. Among different meteorological factors, rainfall seems to be the strongest factor

[ bilobed flap in facial reconstruction]

The spinocellular carcinoma occurs mainly after 40 years old. The excision of these tumors in the cause of loss of substances that pose the problem of reconstruction, especially for tumors localized to the face. The bilobed flap is a useful technique to cover the losses of substances. We describe a 72 years old patient who presents an advanced tumor of the right cheek measuring 6 x 4 cm. we performed a resection of the tumor with a safety margin of 1cm. the reconstruction uses the bilobed flap. The postoperative result is very satisfying. More common for men than for women, this tumor is favored by excessive sun exposure, precancerous skin lesions, genetic diseases [xeroderma pigmentosum], chronic irritation [leukoplakia]. Any suspect lesion should be biopsed. The spinocellular carcinoma spreads quickly locally, spreading to some nearby lump nodes. The treatment of choice for this tumor is surgery. The bilobed flap is particularly suited to reconstract the losses of substances of medium or large size localized to the face. The bilobed flap is a very interesting technique to cover the defect left by excision of a spinocellular carcinoma

[Reconstruction of the upper lip by the radial chinese flap]

The defects of the face pose a problem of reconstruction, it must obey the imperatives of both functional and aesthetic, these requirements are even more pronounced with younger patients. The antibrachial radial flap of [Chinese] flap is an interesting technique for the reconstruction of such loss of substance. We describe the case of a young man of 26 years, victim of a work accident. The lesions involved the scalp, completely avulsed, forehead, right eye, right cheek, the left wing of the nose and upper lip. After replantation of the scalp and right eye enucleation, we used the Chinese flap to cover the defect of the upper lip. The flap was taken from the left forearm and connected to the superior thyroid artery. The postoperative course is simple. The aesthetic and functional results are very satisfactory. The antibrachial radial flap is called [chinese flap] because it was first described in China. It is a strip of low flow and vascular axial meso. Design of the skin paddle is longitudinal or oblique in the forearm, on the radial artery. The one-piece dissection of the radial artery and its septocutaneous branches is in the proximal-distal direction. The proximal dissection dates back to the origin of the radial artery. The donor area is covered by a thin skin graft immediately or secondarily. The Chinese free flap is characterized by a thin and flexible skin perfectly suited to the reconstruction of the face and its excellent vascularization. The disadvantages are unsightly scars on the donor area and the sacrifice of the radial artery. The Chinese flap that we used for the reconstruction of the upper lip has given a very good results on both functional and aesthetic points

[ Mustarde flap]

The main cause of substance loss of the face is a removal of skin tumors by surgical excision which remains an essential treatment of skin cancers. The coverage of these losses of substances must comply with functional and aesthetic requirements. We use in our work the Mustarde flap to cover the defect. We describe the case of a patient who suffers of a basocellular carcinoma. The loss of substance left by the excision is 3 x 4 cm. the flap design goes back horizontally 1 cm below the lower eyelid, extending to the temporal region and down to the front of the ear lobe. A large detachment followed by a rotation of the flap can easily cover the defect. The postoperative course are simple. The aesthetic and functional result is very satisfactory. As an incontestable social element, the face requires a functional and also aesthetic reconstruction to be the closest possible to "ad integrum" restitution as the socio-professional pressure is presently considerable. The Mustarde flap is a flap of skin, thick, with large area and inferior pedicle. The flap design goes above and beyond to outer canthus, swells around the temple area and down to the front of the ear lobe. A movement of medial rotation is printed an external cantholysis allows the possible mobilization of the lateral part when it is stored. To avoid ectropion, it should be securely moored at the temporal and orbital periosteum. The wide separation allowed by subcutaneous flap Mustarde can cover large medial, paranasal, losses of substance. The Mustarde flap is a very interesting technique in the treatment of loss of substance of the face

[Areolar approach to augmentation mammaplasty]

Treatment of breast hypoplasya or hypomastia requires a breast augmentation surgery using implants. The request for surgery remains always a voluntary step of each patient. Beyond the aesthetic improvement that this intervention offers, the psychological repercussion is generally beneficial. However, these implants have side effects and insufficiencies compared to the natural breast. These facts must be perfectly explained to the women who want the breast implants. Let us quote in particular the risk of hematoma or periprosthetic hull which counts among the most serious complications of this type of intervention and which requires an immediate surgical recovery. The aerolar approach to augmentation mammaplasty by implants is an interesting technique in breast augmentation. We report the case of a 36 years old patient who present a breast hypomastia and who profited from this technique

Le traitement chirurgical des gynecomasties [a'propos de deux series de 95 cas]

The management of gynecomastias is mainly surgical and aims to lead to a normal male thoracic morphology with minimal cicatrical damages. The classical technique based on Dufourmentel and Webster principles is still the most used; however, it does not allow to manage all clinical forms of gynecomastia. Through a study of two large series; those of J. Baudet [Bordeaux] including 65 cases [first series] and Grabb [New-York] including 30 cases [second series], we try here to point out the tendencies as for the different surgical approaches, the glandular resection, the eventual cutaneous interventions as well the recent contribution of liposuction to this treatment

Cesarean section and the Cytogenetic investigations of an ischiopagus tetrabrachius tripus

A case of ischiopagus tetrabrachious tripus, born in a Tehran hospital by Cesarean section is reported. Some variations of form from described cases in the literature are outlined. The cytogenetic findings indicated Homokaryotypic MZ twins with 46, XX chromosome constitution. Dermatoglyphic characteristics are presented in the text

pressure within hydatid cysts

The internal fluid pressure of 62 echinococcal hydatid cysts in various organs was measured intraoperatively in 36 patients. Growing hydatid cysts, whether intact univesicular, or previously ruptured multivesicular, demonstrated a fluid pressure distinctly higher than that of surrounding tissues, reflecting viability of the parasitic elements within the cyst. The highest pressure of 98 cm of water, was recorded for a univesicular cyst in the superior portion of the liver. Lung and intra-abdominal cysts registered lower internal pressure. Degenerating cysts showed little or no internal pressure. Relief of its internal fluid pressure seems a logical preliminary step in the surgical management of hydatid cysts